Testosterone hemisuccinate

Base Information

• Chemical Name: Testosterone hemisuccinate
• CAS No.: 521-15-3
• Molecular Formula: C23H32 O5
• Molecular Weight: 388.504
• European Community (EC) Number: 208-305-2
• UNII: 4114I54YIH
• DSSTox Substance ID: DTXSID20966457
• Nikkaji Number: J61.333I
• Wikidata: Q27097818
• Metabolomics Workbench ID: 151743
• Mol file: 521-15-3.mol

Synonyms:T-17-HS;testosterone hemisuccinate;testosterone hydrogen succinate;testosterone-17-hemisuccinate;testosterone-17-succinate;testosterone-17-succinate, sodium salt, (17beta)-isomer

Chemical Property of Testosterone hemisuccinate

Chemical Property:

• Boiling Point: 555.8°Cat760mmHg
• Flash Point: 189.1°C
• PSA: 80.67000
• Density: 1.2g/cm³
• LogP: 4.29490
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 388.22497412
• Heavy Atom Count: 28
• Complexity: 725

Purity/Quality:

99% ^*data from raw suppliers

Testosterone-d317β-Hemisuccinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2OC(=O)CCC(=O)O)CCC4=CC(=O)CCC34C
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCC(=O)O)CCC4=CC(=O)CC[C@]34C
• Uses: Testosterone-d3 17β-Hemisuccinate is the labeled analogue of Testosterone 17β-Hemisuccinate (T155160), which is used in the synthesis of nanopatricles with glycol chitosan (GC) and fructose chitosan (FC) for controlled release testosterone delivery.

Technology Process of Testosterone hemisuccinate

There total 1 articles about Testosterone hemisuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

succinic acid anhydride (108-30-5) + testosterone (58-22-0) → 3-(3-oxo-4-androsten-17β-oxycarbonyl)propionic acid (521-15-3)

Guidance literature:

With pyridine; at 230 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.bmc.2014.05.063

Reference yield:

testosterone (58-22-0) + 3-(3-oxo-4-androsten-17β-oxycarbonyl)propionic acid (521-15-3) → succinic acid bis-(3-oxo-androst-4-en-17β-yl ester) (54697-19-7)

Guidance literature:

Multistep reaction; (i) 1H,1'H-1,1'-carbonyl-bis-imidazole, THF, (ii) /BRN= 1915399/;

DOI:10.1016/0039-128X(74)90015-4

upstream raw materials:

succinic acid anhydride

testosterone

Downstream raw materials:

succinic acid bis-(3-oxo-androst-4-en-17β-yl ester)