{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride

Base Information

• Chemical Name: {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride
• CAS No.: 134978-96-4
• Molecular Formula: C₈H₁₇NO₅*ClH
• Molecular Weight: 243.688
• Mol file: 134978-96-4.mol

Synonyms:{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride

Chemical Property of {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride

There total 2 articles about {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride (134978-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane

2: sodium hydroxide / tetrahydrofuran; toluene / 45 °C

3: hydrogenchloride; water / 1 h

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.ica.2010.07.067

Reference yield:

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride (134978-96-4)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium on carbon; hydrogen / tetrahydrofuran

2: dichloromethane

3: sodium hydroxide / tetrahydrofuran; toluene / 45 °C

4: hydrogenchloride; water / 1 h

With hydrogenchloride; palladium on carbon; water; hydrogen; sodium hydroxide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.ica.2010.07.067

Reference yield: 64.0%

{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride (134978-96-4) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (2-{2-[2-((9H-fluoren-9-ylmethoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-acetic acid (139338-72-0,675606-79-8)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 16.75h;

DOI:10.1016/j.ica.2010.07.067

upstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

2-[2-(2-azidoethoxy)ethoxy]ethanol

Downstream raw materials:

(2-{2-[2-((9H-fluoren-9-ylmethoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-acetic acid