1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

Base Information

Chemical Name:1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile
CAS No.:913827-68-6
Molecular Formula:C₁₇H₁₄N₂O₃
Molecular Weight:294.31
Hs Code.:

Synonyms:1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

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Chemical Property of 1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

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Technology Process of 1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

There total 4 articles about 1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 913827-74-4
3-bromo-1-(2,3-dimethoxyphenyl)propyne

: 89324-17-4,95907-04-3
6-Oxo-1,6-dihydropyridine-2-carbonitrile

: 913827-68-6
1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

Guidance literature:: With sodium hydride; lithium bromide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 65 ℃; for 15h;
DOI:10.1021/ol0620242

Reference yield:

: 25245-33-4
1-iodo-2,3-dimethoxybenzene

: 913827-68-6
1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / triethylamine / Pd(PPh₃)2Cl₂; copper(I) iodide / 12 h / 90 °C

2: triethylamine / CH₂Cl₂ / -50 - 20 °C

3: 181 mg / lithium bromide / CH₂Cl₂; tetrahydrofuran / 12 h / 20 °C

4: 76 percent / sodium hydride; lithium bromide / 1,2-dimethoxy-ethane; dimethylformamide / 15 h / 65 °C

With sodium hydride; triethylamine; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0620242

Reference yield:

: 913827-72-2
3-(2,3-dimethoxyphenyl)-2-propyn-1-ol

: 913827-68-6
1,6-dihydro-1-[3-(2,3-dimethoxyphenyl)-2-propynyl]-6-oxo-2-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / -50 - 20 °C

2: 181 mg / lithium bromide / CH₂Cl₂; tetrahydrofuran / 12 h / 20 °C

3: 76 percent / sodium hydride; lithium bromide / 1,2-dimethoxy-ethane; dimethylformamide / 15 h / 65 °C

With sodium hydride; triethylamine; lithium bromide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0620242