Technology Process of 4-[[4-(2,5-Diamino-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-3-oxo-butyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester
There total 11 articles about 4-[[4-(2,5-Diamino-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-3-oxo-butyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium dithionite;
In
water; N,N-dimethyl-formamide;
at 55 ℃;
for 0.333333h;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 100 percent / H2 / PtO2 / acetic acid / 18 h / 2327.2 Torr
2: 90 percent / 18 h / Ambient temperature
3: thionyl chloride / benzene / 1 h / Heating
4: diethyl ether / 1 h / 25 °C
5: HBr / diethyl ether
6: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
7: p-toluenesulfonic acid / benzene / 6 h / Heating
8: H2 / 10percent Pd/C / 18 h / 517.1 Torr
9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
10: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C
11: 70 percent / sodium ditionite / dimethylformamide; H2O / 0.33 h / 55 °C
With
4-methyl-morpholine; hydrogenchloride; thionyl chloride; sodium azide; sodium dithionite; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; diethyl ether; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 90 percent / 18 h / Ambient temperature
2: thionyl chloride / benzene / 1 h / Heating
3: diethyl ether / 1 h / 25 °C
4: HBr / diethyl ether
5: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
6: p-toluenesulfonic acid / benzene / 6 h / Heating
7: H2 / 10percent Pd/C / 18 h / 517.1 Torr
8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
9: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C
10: 70 percent / sodium ditionite / dimethylformamide; H2O / 0.33 h / 55 °C
With
4-methyl-morpholine; hydrogenchloride; thionyl chloride; sodium azide; sodium dithionite; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00356a004
