2-ethoxy-3-fluoroacetophenone

Base Information

Chemical Name:2-ethoxy-3-fluoroacetophenone
CAS No.:1601269-10-6
Molecular Formula:C₁₀H₁₁FO₂
Molecular Weight:182.195
Hs Code.:

Synonyms:2-ethoxy-3-fluoroacetophenone

Suppliers and Price of 2-ethoxy-3-fluoroacetophenone

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Chemical Property of 2-ethoxy-3-fluoroacetophenone

Chemical Property:

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Technology Process of 2-ethoxy-3-fluoroacetophenone

There total 3 articles about 2-ethoxy-3-fluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 64-67-5
diethyl sulfate

: 699-92-3
1-(3-fluoro-2-hydroxyphenyl)-ethanone

: 1601269-10-6
2-ethoxy-3-fluoroacetophenone

Guidance literature:: 1-(3-fluoro-2-hydroxyphenyl)-ethanone; With potassium fluoride; potassium carbonate; In acetone; at 56 ℃; for 0.416667h; Inert atmosphere;

diethyl sulfate; In acetone; at 56 ℃; for 5.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.02.119

Reference yield:

: 29650-44-0
2-fluorophenyl acetate

: 1601269-10-6
2-ethoxy-3-fluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / chlorobenzene / 120 °C / Inert atmosphere; Large scale

2.1: potassium carbonate; potassium fluoride / acetone / 0.42 h / 56 °C / Inert atmosphere

2.2: 5.5 h / 56 °C / Inert atmosphere

With aluminum (III) chloride; potassium fluoride; potassium carbonate; In chlorobenzene; acetone; 1.1: |Fries Phenol Ester Rearrangement;
DOI:10.1016/j.tetlet.2014.02.119

Reference yield:

: 367-12-4
2-fluorophenol

: 1601269-10-6
2-ethoxy-3-fluoroacetophenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tert-butyl methyl ether / 0.25 h / 25 °C / Inert atmosphere; Large scale

1.2: 4 h / 20 - 45 °C / Inert atmosphere; Large scale

2.1: aluminum (III) chloride / chlorobenzene / 120 °C / Inert atmosphere; Large scale

3.1: potassium carbonate; potassium fluoride / acetone / 0.42 h / 56 °C / Inert atmosphere

3.2: 5.5 h / 56 °C / Inert atmosphere

With aluminum (III) chloride; potassium fluoride; potassium carbonate; triethylamine; In tert-butyl methyl ether; chlorobenzene; acetone; 2.1: |Fries Phenol Ester Rearrangement;
DOI:10.1016/j.tetlet.2014.02.119