Technology Process of 2-ethoxy-3-fluoroacetophenone
There total 3 articles about 2-ethoxy-3-fluoroacetophenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(3-fluoro-2-hydroxyphenyl)-ethanone;
With
potassium fluoride; potassium carbonate;
In
acetone;
at 56 ℃;
for 0.416667h;
Inert atmosphere;
diethyl sulfate;
In
acetone;
at 56 ℃;
for 5.5h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2014.02.119
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / chlorobenzene / 120 °C / Inert atmosphere; Large scale
2.1: potassium carbonate; potassium fluoride / acetone / 0.42 h / 56 °C / Inert atmosphere
2.2: 5.5 h / 56 °C / Inert atmosphere
With
aluminum (III) chloride; potassium fluoride; potassium carbonate;
In
chlorobenzene; acetone;
1.1: |Fries Phenol Ester Rearrangement;
DOI:10.1016/j.tetlet.2014.02.119
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tert-butyl methyl ether / 0.25 h / 25 °C / Inert atmosphere; Large scale
1.2: 4 h / 20 - 45 °C / Inert atmosphere; Large scale
2.1: aluminum (III) chloride / chlorobenzene / 120 °C / Inert atmosphere; Large scale
3.1: potassium carbonate; potassium fluoride / acetone / 0.42 h / 56 °C / Inert atmosphere
3.2: 5.5 h / 56 °C / Inert atmosphere
With
aluminum (III) chloride; potassium fluoride; potassium carbonate; triethylamine;
In
tert-butyl methyl ether; chlorobenzene; acetone;
2.1: |Fries Phenol Ester Rearrangement;
DOI:10.1016/j.tetlet.2014.02.119
