4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

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Chemical Name:4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone
CAS No.:955360-38-0
Molecular Formula:C₃₃H₃₇Cl₂N₃O₂
Molecular Weight:578.582
Hs Code.:

Synonyms:4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

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Chemical Property of 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

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Technology Process of 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

There total 10 articles about 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955360-37-9
4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

: 109-70-6
1.3-chlorobromopropane

: 955360-38-0
4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Guidance literature:: With potassium carbonate; In butanone; for 23h; Reflux; Inert atmosphere;
DOI:10.1021/jm1013874

Reference yield:

: 955359-80-5
1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

: 955360-38-0
4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane

2: potassium carbonate / butanone / 20 h / Reflux

3: boron tribromide / dichloromethane / 18 h / -60 - 20 °C / Inert atmosphere

4: potassium carbonate / butanone / 23 h / Reflux; Inert atmosphere

With hydrogenchloride; boron tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane; butanone;
DOI:10.1021/jm1013874

Reference yield:

: 955359-81-6
4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

: 955360-38-0
4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / butanone / 20 h / Reflux

2: boron tribromide / dichloromethane / 18 h / -60 - 20 °C / Inert atmosphere

3: potassium carbonate / butanone / 23 h / Reflux; Inert atmosphere

With boron tribromide; potassium carbonate; In dichloromethane; butanone;
DOI:10.1021/jm1013874