1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate
CAS No.:955359-80-5
Molecular Formula:C₂₅H₂₈ClN₃O₃
Molecular Weight:453.969
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Suppliers and Price of 1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

There total 5 articles about 1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 53242-88-9
4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 955359-80-5
1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/jm1013874

Reference yield:

: 53242-88-9
4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

: 59378-81-3,69610-40-8,83435-58-9
1-(tert-butoxycarbonyl)prolin-2R-ol

: 955359-80-5
1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -15 - 20 ℃;

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 955359-80-5
1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / 1-methyl-pyrrolidin-2-one / 48 h / 200 °C

2.1: hydrazine / ethanol / 15 h / 85 °C

2.2: 2 h / 2 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 20 °C

With di-isopropyl azodicarboxylate; sodium acetate; triphenylphosphine; hydrazine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol;