4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Base Information

Chemical Name:4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone
CAS No.:955359-81-6
Molecular Formula:C₂₀H₂₀ClN₃O
Molecular Weight:353.851
Hs Code.:

Synonyms:4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

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Technology Process of 4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

There total 6 articles about 4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 955359-80-5
1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

: 955359-81-6
4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1021/jm1013874

Reference yield:

: 53242-88-9
4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

: 955359-81-6
4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction;
DOI:10.1021/jm1013874

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 955359-81-6
4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction;
DOI:10.1021/jm1013874