(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

Base Information

Chemical Name:(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline
CAS No.:73746-69-7
Molecular Formula:C₁₈H₂₉NO₃Si
Molecular Weight:335.519
Hs Code.:

Synonyms:(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

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Technology Process of (4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

There total 12 articles about (4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52075-14-6
(4S,5S)-(-)-4,5-dihydro-4-methoxymethyl-2-methyl-5-phenyloxazole

: 73746-69-7
(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C 2) up to -50 deg C

2: 1) lithium diisopropylamide / 1) THF / -78 deg C 2a) -98 deg C / 2h 2b) -78 deg C / 5h

3: 4.5N HCl / Heating

4: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

5: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009

Reference yield:

: 73713-17-4
(4S,5S)-2-n-Pentyl-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 73746-69-7
(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C 2) -98 deg C

2: 4.5N HCl / Heating

3: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

4: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009

Reference yield:

: 2427-16-9
5-hydroxy-pentanenitrile

: 73746-69-7
(4S,5S)-2-<4-<(Trimethylsilyl)oxy>butyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / 3 h / 0 °C

2: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

3: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009