C₂₄H₂₆Cl₃N₃O₄

Base Information

• Chemical Name: C₂₄H₂₆Cl₃N₃O₄
• CAS No.: 1284260-33-8
• Molecular Formula: C₂₄H₂₆Cl₃N₃O₄
• Molecular Weight: 526.847
• Mol file: 1284260-33-8.mol

Synonyms:C₂₄H₂₆Cl₃N₃O₄

Chemical Property of C₂₄H₂₆Cl₃N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₆Cl₃N₃O₄

There total 3 articles about C₂₄H₂₆Cl₃N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{4-[(4-aminobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-81-6) + 2-chloro-6-methyl nicotinic acid (30529-70-5) → C24H26Cl3N3O4 (1284260-33-8)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.01.068

Reference yield:

1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-80-5) → C24H26Cl3N3O4 (1284260-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated charcoal; hydrogen / methanol / 0.83 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.01.068

Reference yield:

ethacrynic acid (58-54-8) → C24H26Cl3N3O4 (1284260-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere

2: 10% palladium on activated charcoal; hydrogen / methanol / 0.83 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.068

upstream raw materials:

1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

1-{4-[(4-aminobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

2-chloro-6-methyl nicotinic acid

ethacrynic acid