(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one
CAS No.:1043450-45-8
Molecular Formula:C₂₇H₃₄F₂N₂O₄
Molecular Weight:488.575
Hs Code.:

Synonyms:(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

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Chemical Property of (S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

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Technology Process of (S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

There total 9 articles about (S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261951-68-2
4-fluoro-3-methylbenzylamine

: 1043450-44-7
(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

: 1043450-45-8
(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1043450-40-3
2-(4-fluoro-3-methylphenoxy)acetyl chloride

: 1043450-45-8
(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

1.2: 2 h / -70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

2.2: 1 h / -70 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

With n-butyllithium; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1043450-39-0
ethyl 2-(4-fluoro-3-methylphenoxy)acetate

: 1043450-45-8
(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 0.5 h / 20 - 25 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

3.2: 2 h / -70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

4.2: 1 h / -70 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

7.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; water; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; 1,2-dichloro-ethane;