Technology Process of 1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene
There total 10 articles about 1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3 A molecular sieve; pyridinium chlorochromate;
In
dichloromethane;
for 4h;
Ambient temperature;
DOI:10.1021/jo00383a032
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / pyridine / 12 h / Heating
2: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h
3: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH2Cl2 / 4 h / Ambient temperature
With
pyridine; n-butyllithium; 3 A molecular sieve; pyridinium chlorochromate;
In
dichloromethane;
DOI:10.1021/jo00383a032
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) potassium tert-butoxide / 1.) dioxane, RT, 1.5 h, 2.) dioxane, RT, 22 h
2: p-toluenesulfonic acid monohydrate / dioxane; H2O / 14 h / Heating
3: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h
4: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH2Cl2 / 4 h / Ambient temperature
With
n-butyllithium; 3 A molecular sieve; potassium tert-butylate; toluene-4-sulfonic acid; pyridinium chlorochromate;
In
1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo00383a032
