1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

Base Information

Chemical Name:1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene
CAS No.:107135-60-4
Molecular Formula:C₂₇H₂₄O₄
Molecular Weight:412.485
Hs Code.:

Synonyms:1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

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Chemical Property of 1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

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Technology Process of 1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

There total 10 articles about 1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 161321-77-3
2,3-dihydro-7-methoxy-1--1H-indene

: 107135-60-4
1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

Guidance literature:: With 3 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jo00383a032

Reference yield:

: 13146-23-1
copper(I) phenylacetylenide

: 107135-60-4
1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / pyridine / 12 h / Heating

2: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h

3: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; n-butyllithium; 3 A molecular sieve; pyridinium chlorochromate; In dichloromethane;
DOI:10.1021/jo00383a032

Reference yield:

: 34985-41-6
7-methoxy-indan-1-one

: 107135-60-4
1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide / 1.) dioxane, RT, 1.5 h, 2.) dioxane, RT, 22 h

2: p-toluenesulfonic acid monohydrate / dioxane; H₂O / 14 h / Heating

3: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h

4: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH₂Cl₂ / 4 h / Ambient temperature

With n-butyllithium; 3 A molecular sieve; potassium tert-butylate; toluene-4-sulfonic acid; pyridinium chlorochromate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo00383a032