7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Base Information

Chemical Name:7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline
CAS No.:1312686-29-5
Molecular Formula:C₁₇H₁₂ClFN₄
Molecular Weight:326.76
Hs Code.:

Synonyms:7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Suppliers and Price of 7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

There total 10 articles about 7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312686-30-8
1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

: 1312686-29-5
7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1312686-29-5
7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-Bromosuccinimide / acetic acid / 18 h / 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 1 h / 200 °C

3.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2 h / 80 °C

5.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / Reflux

6.1: sulfuric acid / water / 0 °C

6.2: 1 h / 60 °C

7.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - 20 °C

7.2: 1 h

8.1: sodium acetate; ammonium chloride / water; tetrahydrofuran / 20 °C

9.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

10.1: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

With N-Bromosuccinimide; sodium azide; sulfuric acid; sodium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; ammonium chloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; hexane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312686-22-8
3-acetyl-5-chloro-2-hydroxy-6-methylbenzonitrile

: 1312686-29-5
7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2 h / 80 °C

3.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / Reflux

4.1: sulfuric acid / water / 0 °C

4.2: 1 h / 60 °C

5.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - 20 °C

5.2: 1 h

6.1: sodium acetate; ammonium chloride / water; tetrahydrofuran / 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

With N-Bromosuccinimide; sodium azide; sulfuric acid; sodium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; ammonium chloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;