1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

Base Information

Chemical Name:1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate
CAS No.:1312686-30-8
Molecular Formula:C₁₈H₁₅ClFNO₃S
Molecular Weight:379.839
Hs Code.:

Synonyms:1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

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Chemical Property of 1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

Chemical Property:

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Technology Process of 1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

There total 9 articles about 1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312686-28-4
1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethanol

: 124-63-0
methanesulfonyl chloride

: 1312686-30-8
1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1312686-30-8
1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / acetic acid / 18 h / 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 1 h / 200 °C

3.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2 h / 80 °C

5.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / Reflux

6.1: sulfuric acid / water / 0 °C

6.2: 1 h / 60 °C

7.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - 20 °C

7.2: 1 h

8.1: sodium acetate; ammonium chloride / water; tetrahydrofuran / 20 °C

9.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With N-Bromosuccinimide; sulfuric acid; sodium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; ammonium chloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; hexane; dichloromethane; water; acetic acid; toluene;

Reference yield:

: 1312686-24-0
6-acetyl-4-chloro-3'-fluoro-3-methylbiphenyl-2-carbonitrile

: 1312686-30-8
1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / Reflux

2.1: sulfuric acid / water / 0 °C

2.2: 1 h / 60 °C

3.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - 20 °C

3.2: 1 h

4.1: sodium acetate; ammonium chloride / water; tetrahydrofuran / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With N-Bromosuccinimide; sulfuric acid; sodium acetate; diisobutylaluminium hydride; ammonium chloride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; water;