1-methyl-3-(phenylmethyl)-1H-indole

Base Information

• Chemical Name: 1-methyl-3-(phenylmethyl)-1H-indole
• CAS No.: 24486-66-6
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.302
• Mol file: 24486-66-6.mol

Synonyms:1-methyl-3-(phenylmethyl)-1H-indole

Chemical Property of 1-methyl-3-(phenylmethyl)-1H-indole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3-(phenylmethyl)-1H-indole

There total 19 articles about 1-methyl-3-(phenylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(1-methyl-1H-indol-3-yl)(phenyl)methanol (1908-67-4) → 1-methyl-3-(phenylmethyl)-1H-indole (24486-66-6)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; toluene-4-sulfonic acid; In chloroform; at 25 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2014.05.064

Reference yield: 90.0%

N,N-dimethyl-2-(2-phenylethynyl)aniline (54655-08-2) → 1-methyl-3-(phenylmethyl)-1H-indole (24486-66-6)

Guidance literature:

With C₇₆H₁₀₄ClIrO₈P₂; In 1,3,5-trimethyl-benzene; at 150 ℃; for 6h; Reagent/catalyst; Catalytic behavior;

DOI:10.1055/a-1511-1025

Reference yield: 86.0%

3-Phenyl-1-propanol (122-97-4) + 1-Methyl-1-phenylhydrazine (618-40-6) → 1-methyl-3-(phenylmethyl)-1H-indole (24486-66-6)

Guidance literature:

With but-2-enenitrile; dodecacarbonyl-triangulo-triruthenium; 2,2'-bis(diphenylphosphino)biphenyl; zinc(II) chloride; In tert-Amyl alcohol; at 130 ℃; for 3h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ol3030956

upstream raw materials:

1-methylgramine methiodide

1-(N-methyl-anilino)-3-phenyl-acetone

aniline hydrochloride

aniline

Downstream raw materials:

3-benzoyl-1-methylindole

Refernces

• 1、 La Manna, Pellegrino,Talotta, Carmen,Floresta, Giuseppe,De Rosa, Margherita,Soriente, Annunziata,Rescifina, Antonio,Gaeta, Carmine,Neri, Placido. "Mild Friedel–Crafts Reactions inside a Hexameric Resorcinarene Capsule: C?Cl Bond Activation through Hydrogen Bonding to Bridging Water Molecules". . p. 5423 - 5428. Retrieved 2018/04/09.
• 2、 Chen, Cai,Feng, Huan-Xi,Li, Zhi-Long,Cai, Pin-Wen,Liu, Yan-Kai,Shan, Lian-Hai,Zhou, Xian-Li. "A highly efficient route to C-3 alkyl-substituted indoles via a metal-free transfer hydrogenation". supporting information. p. 3774 - 3776. Retrieved 2014/07/07.