(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid

Base Information

• Chemical Name: (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid
• CAS No.: 1246843-12-8
• Molecular Formula: C₁₉H₂₉NO₅
• Molecular Weight: 351.443
• Mol file: 1246843-12-8.mol

Synonyms:(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid

Chemical Property of (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid

There total 1 articles about (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Boc-D-Tyr(t-Bu)-OH (507276-74-6) + methyl iodide (74-88-4) → (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid (1246843-12-8)

Guidance literature:

Boc-D-Tyr(t-Bu)-OH; methyl iodide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With citric acid; In water; pH=3; Inert atmosphere;

DOI:10.1021/ol101801u

Reference yield: 96.0%

(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid (1246843-12-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (R)-tert-butyl 3-(4-tert-butoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl(methyl)carbamate (1246843-13-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol101801u

Reference yield:

(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid (1246843-12-8) + C14H16N2O3 → C33H43N3O7 (1598418-57-5)

Guidance literature:

C₁₄H₁₆N₂O₃; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.061

upstream raw materials:

Boc-D-Tyr(t-Bu)-OH

methyl iodide

Downstream raw materials:

(R)-tert-butyl 3-(4-tert-butoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl(methyl)carbamate

(R)-tert-butyl 1-(4-tert-butoxyphenyl)-3-oxohept-6-en-2-yl(methyl)carbamate

tert-butyl (2R,3R)-1-(4-tert-butoxyphenyl)-3-hydroxyhept-6-en-2-yl(methyl)carbamate

(2R,3R)-2-(tert-butoxycarbonyl(methyl)amino)-1-(4-tert-butoxyphenyl)hept-6-en-3-yl acetate