(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

Base Information

Chemical Name:(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride
CAS No.:688756-19-6
Molecular Formula:C₂₀H₁₃Cl₃F₃N₃O₄S
Molecular Weight:554.761
Hs Code.:

Synonyms:(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

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Chemical Property of (R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

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Technology Process of (R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

There total 11 articles about (R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (R)-1-(3,5-dichloro-phenyl)-5-iodo-3-methyl-3-(4-trifluoromethoxy-benzyl)-1H-imidazo[1,2-a]imidazole-2-one

: 688756-19-6
(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

Guidance literature:: (R)-1-(3,5-dichloro-phenyl)-5-iodo-3-methyl-3-(4-trifluoromethoxy-benzyl)-1H-imidazo[1,2-a]imidazole-2-one; With sulfur dioxide; cyclopentylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -40 ℃; for 1.19167h;

at -20 - 20 ℃; for 14.5h;

With N-chloro-succinimide; In tetrahydrofuran; at -20 ℃; for 1.08333h;

Reference yield:

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

: 688756-19-6
(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / isopropyl alcohol / 1 h / 60 °C

1.2: 3 h / 60 °C

2.1: 3 h / 60 °C

3.1: 2.5 h / 10 - 20 °C

3.2: 2 h / 40 - 50 °C

4.1: 1.5 h / 10 - 20 °C

5.1: 0.92 h / -15 - -5 °C

5.2: 0.75 h / -15 - -5 °C

5.3: 0.67 h / -5 °C

With potassium hydroxide; In isopropyl alcohol;
DOI:10.1021/op200175t

Reference yield:

: C₇H₈O₃S*C₉H₁₀Cl₂N₂O

: 688756-19-6
(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; sodium hydroxide / ethyl acetate / 0.5 h

1.2: 10.5 h / 17 - 23 °C / Reflux

1.3: 12 h / 50 °C

2.1: 3 h / 0 - 20 °C

3.1: 1.5 h / 0 - 5 °C

4.1: potassium hydroxide / isopropyl alcohol / 1 h / 60 °C

4.2: 3 h / 60 °C

5.1: 3 h / 60 °C

6.1: 2.5 h / 10 - 20 °C

6.2: 2 h / 40 - 50 °C

7.1: 1.5 h / 10 - 20 °C

8.1: 0.92 h / -15 - -5 °C

8.2: 0.75 h / -15 - -5 °C

8.3: 0.67 h / -5 °C

With water; potassium hydroxide; sodium hydroxide; In ethyl acetate; isopropyl alcohol;
DOI:10.1021/op200175t