3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide

Base Information

• Chemical Name: 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide
• CAS No.: 1254318-25-6
• Molecular Formula: C₂₁H₁₉F₉N₂O₂
• Molecular Weight: 502.38
• Mol file: 1254318-25-6.mol

Synonyms:3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide

Chemical Property of 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide

There total 7 articles about 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy-3-nitrobenzamide (1254318-22-3) → 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide (1254318-25-6)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In water; isopropyl alcohol; at 0 - 80 ℃; for 0.5h;

Reference yield:

2-bromo-3-nitro-benzoic acid (573-54-6) → 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide (1254318-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 100 °C

2.1: pyridine / tetrahydrofuran / 18 h / 0 °C / Reflux

2.2: 41 h / 20 °C

3.1: potassium carbonate / 16 h / 20 °C

4.1: tin(ll) chloride; hydrogenchloride / isopropyl alcohol; water / 0.5 h / 0 - 80 °C

With pyridine; hydrogenchloride; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; water; isopropyl alcohol; toluene;

Reference yield:

2-fluoro-3-nitro-benzoic acid (317-46-4) → 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide (1254318-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4 h / 20 °C / Reflux

2: pyridine / tetrahydrofuran / 6 h / 20 °C / Reflux

3: potassium carbonate / 16 h / 20 °C

4: tin(ll) chloride; hydrogenchloride / isopropyl alcohol; water / 0.5 h / 0 - 80 °C

With pyridine; hydrogenchloride; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy-3-nitrobenzamide

2-fluoro-3-nitro-benzoyl chloride

2-bromo-3-nitro-benzoic acid

2-bromo-3-nitrobenzoic acid chloride

Downstream raw materials:

N-{3-[2-bromo-6-chloro-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-phenylcarbamoyl]-2-methoxyphenyl}-2,4,6-trifluorobenzamide

C₂₅H₁₄BrClF₁₀N₂O₃

C₂₈H₂₂ClF₉N₂O₃

N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyanobenzoylamino)-2-methoxybenzamide

Refernces

• 1、 -. "INSECTICIDAL COMPOUNDS". Page/Page column 30. . Retrieved 2010/11/18.