2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

Base Information

Chemical Name:2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone
CAS No.:1252765-77-7
Molecular Formula:C₂₄H₂₂F₄N₄O₂
Molecular Weight:474.458
Hs Code.:

Synonyms:2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

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Chemical Property of 2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

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Technology Process of 2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

There total 7 articles about 2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1252765-77-7
2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide / 2.5 h / 220 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran; water / 18 h / 55 °C / Inert atmosphere

3: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With copper(l) iodide; potassium carbonate; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 77278-37-6
4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylic acid tert-butyl ester

: 1252765-77-7
2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / Reflux

3: carbonochloridic acid 1-chloro-ethyl ester; methanol / dichloromethane / 2.5 h / 0 °C / Inert atmosphere; Reflux

4: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With methanol; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 6511-88-2
2,2,2-trifluoro-1-(piperazine-1-yl)ethane-1-one

: 1252765-77-7
2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / Reflux

2: carbonochloridic acid 1-chloro-ethyl ester; methanol / dichloromethane / 2.5 h / 0 °C / Inert atmosphere; Reflux

3: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With methanol; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; acetonitrile;