1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone
CAS No.:1252779-85-3
Molecular Formula:C₂₂H₂₄F₃N₃O
Molecular Weight:403.447
Hs Code.:

Synonyms:1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

There total 3 articles about 1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33301-41-6
1-benzhydryl-3-azetidinyl methanesulfonate

: 6511-88-2
2,2,2-trifluoro-1-(piperazine-1-yl)ethane-1-one

: 1252779-85-3
1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

Guidance literature:: 1-benzhydryl-3-azetidinyl methanesulfonate; 2,2,2-trifluoro-1-(piperazine-1-yl)ethane-1-one; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Reflux;

With hydrogenchloride; In dichloromethane; water;

With sodium hydroxide; In dichloromethane; water; pH=10;

Reference yield:

: 36476-82-1
1-(diphenylmethyl)-3-methoxyazetidine

: 6511-88-2
2,2,2-trifluoro-1-(piperazine-1-yl)ethane-1-one

: 1252779-85-3
1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2h; Reflux;

Reference yield:

: 77278-37-6
4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylic acid tert-butyl ester

: 1252779-85-3
1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / Reflux

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;