4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

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Chemical Name:4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide
CAS No.:1621707-02-5
Molecular Formula:C₂₃H₂₇N₅O₆
Molecular Weight:469.497
Hs Code.:

Synonyms:4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

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Chemical Property of 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

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Technology Process of 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

There total 5 articles about 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1352568-78-5
2-(cyclohexylcarbonyl)-10-hydroxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 4-bromomethylfuroxan-3-carboxamide

: 1621707-02-5
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

Guidance literature:: 2-(cyclohexylcarbonyl)-10-hydroxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; With sodium hydride; In tetrahydrofuran; mineral oil; for 1.5h; Reflux;

4-bromomethylfuroxan-3-carboxamide; In tetrahydrofuran; mineral oil; at 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1621707-02-5
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dichloromethane / 4 h / Reflux

2.1: methanol / 48 h / 20 °C

3.1: methanesulfonic acid / 5 h / 0 - 70 °C

4.1: boron tribromide / dichloromethane / 3 h / 20 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux

5.2: 2 h / 60 °C

With methanesulfonic acid; N-benzyl-N,N,N-triethylammonium chloride; boron tribromide; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 2.1: |Ugi Condensation / 3.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 1-(2-isocyanoethyl)-4-methoxybenzene

: 1621707-02-5
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 48 h / 20 °C

2.1: methanesulfonic acid / 5 h / 0 - 70 °C

3.1: boron tribromide / dichloromethane / 3 h / 20 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux

4.2: 2 h / 60 °C

With methanesulfonic acid; boron tribromide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil; 1.1: |Ugi Condensation / 2.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007