4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

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Chemical Name:4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile
CAS No.:1621707-03-6
Molecular Formula:C₂₃H₂₅N₅O₅
Molecular Weight:451.482
Hs Code.:

Synonyms:4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

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Chemical Property of 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

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Technology Process of 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

There total 6 articles about 4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1621707-02-5
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carboxamide

: 1621707-03-6
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

Guidance literature:: With pyridine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1621707-03-6
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dichloromethane / 4 h / Reflux

2.1: methanol / 48 h / 20 °C

3.1: methanesulfonic acid / 5 h / 0 - 70 °C

4.1: boron tribromide / dichloromethane / 3 h / 20 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux

5.2: 2 h / 60 °C

6.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 0.75 h / 0 - 20 °C

With pyridine; methanesulfonic acid; N-benzyl-N,N,N-triethylammonium chloride; boron tribromide; sodium hydride; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 2.1: |Ugi Condensation / 3.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 1-(2-isocyanoethyl)-4-methoxybenzene

: 1621707-03-6
4-({[2-(cyclohexylcarbonyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-10-yl]oxy}methyl)furoxan-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 48 h / 20 °C

2.1: methanesulfonic acid / 5 h / 0 - 70 °C

3.1: boron tribromide / dichloromethane / 3 h / 20 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux

4.2: 2 h / 60 °C

5.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 0.75 h / 0 - 20 °C

With pyridine; methanesulfonic acid; boron tribromide; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil; 1.1: |Ugi Condensation / 2.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007