5-(hydroxymethyl)-2-methylbenzoic acid

Base Information Edit

Chemical Name:5-(hydroxymethyl)-2-methylbenzoic acid
CAS No.:72985-21-8
Molecular Formula:C₉H₁₀O₃
Molecular Weight:166.177
Hs Code.:
Mol file:72985-21-8.mol

Synonyms:5-(hydroxymethyl)-2-methylbenzoic acid

Suppliers and Price of 5-(hydroxymethyl)-2-methylbenzoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of 5-(hydroxymethyl)-2-methylbenzoic acid Edit

Chemical Property:

Boiling Point:359.1±30.0 °C(Predicted)
Density:1.258±0.06 g/cm3(Predicted)

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

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Technology Process of 5-(hydroxymethyl)-2-methylbenzoic acid

There total 7 articles about 5-(hydroxymethyl)-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.85%

: 124-38-9,18923-20-1
carbon dioxide

: 68120-35-4
(3-bromo-4-methyl-phenyl)-methanol

: 72985-21-8
5-(hydroxymethyl)-2-methylbenzoic acid

Guidance literature:: (3-bromo-4-methyl-phenyl)-methanol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; for 0.166667h;

Reference yield: 16.0%

: 610-72-0
2,5-dimethylbenzoic acid

: 72985-23-0
6-methylisobenzofuran-1(3H)-one

: 72985-21-8
5-(hydroxymethyl)-2-methylbenzoic acid

: 72985-20-7
2-bromomethyl-5-methylbenzoic acid

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane; 1.) Irradiation, 3 h, 2.) reflux, 3 h;
DOI:10.1021/jo01296a018

Reference yield:

: 36276-24-1
3-bromo-4-methyl-benzaldehyde

: 72985-21-8
5-(hydroxymethyl)-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.17 h

With methanol; sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran;