Benzoic acid, 5-formyl-2-methyl-

Base Information

• Chemical Name: Benzoic acid, 5-formyl-2-methyl-
• CAS No.: 105650-34-8
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Hs Code.: 2918300090
• Mol file: 105650-34-8.mol

Synonyms:5-formyl-2-methylbenzoic acid;

Chemical Property of Benzoic acid, 5-formyl-2-methyl-

Chemical Property:

• PSA: 54.37000
• LogP: 1.50570

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

5-Formyl-2-methylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 5-formyl-2-methyl-

There total 9 articles about Benzoic acid, 5-formyl-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-methylbenzoic acid (79669-49-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-formyl-2-methylbenzoic acid (105650-34-8)

Guidance literature:

5-bromo-2-methylbenzoic acid; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ml300335r

Reference yield:

5-(hydroxymethyl)-2-methylbenzoic acid (72985-21-8) → 5-formyl-2-methylbenzoic acid (105650-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonic acid / 3 h / 0 - 65 °C

2: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

3: water; sodium hydroxide / ethanol; tetrahydrofuran

With methanesulfonic acid; water; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

methyl 5-formyl-2-methylbenzoate (675148-96-6) → 5-formyl-2-methylbenzoic acid (105650-34-8)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; ethanol;

upstream raw materials:

5-bromo-2-methylbenzoic acid

N,N-dimethyl-formamide

4-methyl-benzaldehyde

3-bromo-4-methyl-benzaldehyde

Downstream raw materials:

4-(1-(2-methyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

methyl 5-formyl-2-methylbenzoate

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