3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Chemical Name:3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
CAS No.:1356599-40-0
Molecular Formula:C₃₀H₃₀N₂O₆
Molecular Weight:514.578
Hs Code.:

Synonyms:3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Chemical Property of 3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Technology Process of 3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

There total 12 articles about 3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356600-26-4
2-(4-(bromomethyl)phenoxy)-1-phenylethanone O-methyl oxime

: 1356601-04-1
3-[2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-hydroxyphenyl]propanoic acid

: 1356599-40-0
3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; acetonitrile; at 0 - 20 ℃; for 5h;

Reference yield:

: 300-87-8
3,5-dimethyl-1,2-oxazole

: 1356599-40-0
3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 75 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -65 °C

2.2: 16 h / -78 - 20 °C

2.3: 20 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 5 h / 95 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

4.2: 0 °C

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 16 h / 20 °C

5.2: pH 2

6.1: sodium hydroxide / acetonitrile; ethanol / 5 h / 0 - 20 °C

With N-Bromosuccinimide; n-butyllithium; water; boron tribromide; sodium hydrogencarbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 10558-25-5
4-bromo-3,5-dimethyl-1,2-oxazole

: 1356599-40-0
3-{2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -65 °C

1.2: 16 h / -78 - 20 °C

1.3: 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 5 h / 95 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

3.2: 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 16 h / 20 °C

4.2: pH 2

5.1: sodium hydroxide / acetonitrile; ethanol / 5 h / 0 - 20 °C

With n-butyllithium; water; boron tribromide; sodium hydrogencarbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;