4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

Base Information

Chemical Name:4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol
CAS No.:1609655-22-2
Molecular Formula:C₂₁H₂₅F₃N₂O
Molecular Weight:378.438
Hs Code.:

Synonyms:4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

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Chemical Property of 4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

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Technology Process of 4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

There total 4 articles about 4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1609654-73-0
5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

: 1609655-22-2
4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 22h; Inert atmosphere;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609655-22-2
4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

3.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 22 h / 20 °C / Inert atmosphere

With bromine; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; 2.1: |Duff Aldehyde Synthesis / 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;

Reference yield:

: 2198-66-5
2-bromo-4-tert-butylphenol

: 1609655-22-2
4-(tert-butyl)-2-(pyrrolidin-1-ylmethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

2.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 22 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: |Duff Aldehyde Synthesis / 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;