Technology Process of C16H13NOS2
There total 2 articles about C16H13NOS2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(phenylthio)-1,3-thiazole;
With
bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Inert atmosphere;
para-iodoanisole;
With
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/jo201250n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: TurboGrignard / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
1.2: 0.5 h / -40 °C / Inert atmosphere
2.1: bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
2.2: 3 h / 25 °C / Inert atmosphere
With
TurboGrignard; bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex;
In
tetrahydrofuran;
2.2: Negishi coupling reaction;
DOI:10.1021/jo201250n
- Guidance literature:
-
C16H13NOS2;
With
bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Inert atmosphere;
para-iodoanisole;
With
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; trifuran-2-yl-phosphane;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo201250n
