2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

Base Information

Chemical Name:2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester
CAS No.:203921-96-4
Molecular Formula:C₂₆H₂₈O₉
Molecular Weight:484.503
Hs Code.:

Synonyms:2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

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Chemical Property of 2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

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Technology Process of 2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

There total 7 articles about 2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: allyl 2,2-dimethoxyethyl malonate

: 182201-73-6
7-methyl-6-phenylmethoxy-1,3-benzodioxole-5-carbaldehyde

: 203921-96-4
2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

Guidance literature:: With piperidine; acetic acid; In benzene; at 23 ℃; for 18h;
DOI:10.1021/ja962480t

Reference yield:

: 100-39-0
benzyl bromide

: 203921-96-4
2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 23 deg C, 40 min

2: 99 percent / piperidine, acetic acid / benzene / 18 h / 23 °C

With piperidine; sodium hydride; acetic acid; In benzene;
DOI:10.1021/ja962480t

Reference yield:

: 111726-43-3
3,4-(methylenedioxy)phenyl methoxymethyl ether

: 203921-96-4
2-[1-(6-Benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-malonic acid allyl ester 2,2-dimethoxy-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) BuLi, tetramethylethylene diamine / 1.) hexane, 0 deg C, 4 h, 2.) hexane, from -78 deg C to 23 deg C, 15 min

2: 1.) BuLi / 1.) THF, -30 deg C, 13 h

3: CH₃SO₃H / CH₂Cl₂ / 0 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 23 deg C, 40 min

5: 99 percent / piperidine, acetic acid / benzene / 18 h / 23 °C

With piperidine; n-butyllithium; methanesulfonic acid; N,N,N,N,-tetramethylethylenediamine; sodium hydride; acetic acid; In dichloromethane; benzene;
DOI:10.1021/ja962480t