[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

Base Information

Chemical Name:[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide
CAS No.:1025070-12-5
Molecular Formula:C₅₀H₇₇NO₆
Molecular Weight:788.164
Hs Code.:

Synonyms:[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

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Chemical Property of [(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

Chemical Property:

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Technology Process of [(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

There total 11 articles about [(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₆H₆₇ClO₅

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1025070-12-5
[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 5 - 20 ℃; for 24.05h;

Reference yield:

: 10376-50-8,38736-81-1
3-O-acetylbetulinic acid

: 1025070-12-5
[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.2: 72 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

3.2: 0 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 5 - 20 °C

5.1: tetrahydrofuran; hexane / 0.5 h / -60 - 30 °C

5.2: 20 h / -60 - 20 °C

6.1: sodium tetrahydroborate; nickel dichloride / methanol / 4.03 h / 20 °C

6.2: 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran / 48 h / 20 °C

7.2: pH 3

8.1: oxalyl dichloride / dichloromethane / 2 h / 5 - 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24.05 h / 5 - 20 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; nickel dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

Betulinic acid: 472-15-1
Betulinic acid

: 1025070-12-5
[(3β)-N-(2-hydroxy-1,1-dimethylethyl)-3-[4-(phenylmethoxy)carbonyl-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-yl]acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 65 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.2: 72 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

4.2: 0 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 5 - 20 °C

6.1: tetrahydrofuran; hexane / 0.5 h / -60 - 30 °C

6.2: 20 h / -60 - 20 °C

7.1: sodium tetrahydroborate; nickel dichloride / methanol / 4.03 h / 20 °C

7.2: 20 °C

8.1: lithium hydroxide; water / tetrahydrofuran / 48 h / 20 °C

8.2: pH 3

9.1: oxalyl dichloride / dichloromethane / 2 h / 5 - 20 °C

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24.05 h / 5 - 20 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; nickel dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane;