Technology Process of Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester
There total 6 articles about Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C
2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
3: 91 percent / H2 / 5percent Pd/C / methanol; acetic acid / 21 h
4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C
5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
With
4-methyl-morpholine; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C
2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
3: 91 percent / H2 / 5percent Pd/C / methanol; acetic acid / 21 h
4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C
5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1039/a702410j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd/C / methanol; acetic acid / 21 h
3: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C
4: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature
With
4-methyl-morpholine; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j