R-1,2-Propanediol

Base Information

• Chemical Name: R-1,2-Propanediol
• CAS No.: 4254-14-2
• Molecular Formula: C3H8O2
• Molecular Weight: 76.0953
• Hs Code.: 29053200
• NSC Number: 90793
• UNII: 602HN5L69H
• DSSTox Substance ID: DTXSID201009429
• Nikkaji Number: J9.257F
• Wikidata: Q27093218
• RXCUI: 1314303
• Metabolomics Workbench ID: 51909
• Mol file: 4254-14-2.mol

Synonyms:4254-14-2;(R)-(-)-1,2-Propanediol;(R)-Propane-1,2-diol;(2R)-propane-1,2-diol;R-1,2-PROPANEDIOL;(R)-1,2-Propanediol;(R)-Propylene glycol;R-(-)-1,2-propanediol;(2R)-1,2-propanediol;(R)-(-)-1,2-Dihydroxypropane;(-)-1,2-Propanediol;1,2-Propanediol, (R)-;1-Deoxy-sn-glycerol;D-(-)-Propanediol;(-)-Propylene glycol;Propylene glycol, (R)-;R-(-)-Propylene glycol;Propylene glycol, (2R)-;NSC-90793;(R)-2-Hydroxy-1-propanol;1,2-Propanediol, (R)-(-)-;(R)-(-)-Propylene glycol;(R)-(-)-Propylene glycerol;UNII-602HN5L69H;602HN5L69H;propylenglycol;Prolugen;16922-04-6;propylene-glycol;Ilexan P;Propylene glycol #;MFCD00066248;Aliphatic alcohol;Chilisa FE;a-Propylene glycol;D-1,2-propanediol;PROPYLENE GLYCOL L-FORM;Inhibited 1,2-propylene glycol;CHEBI:28972;DTXSID201009429;HY-Z0031;NSC90793;PROPYLENE GLYCOL L-FORM [MI];AKOS015840306;CS-W020032;DB02159;(R)-(-)-1,2-Propanediol, 96%;AC-14032;AS-12361;P1152;C02912;EN300-201235;A825932;A905496;Q27093218;Z1255486379

Chemical Property of R-1,2-Propanediol

Chemical Property:

• Appearance/Colour: colorless to light yellow liquid
• Vapor Pressure: 0.204mmHg at 25°C
• Melting Point: -57 °C
• Refractive Index: n20/D 1.434(lit.)
• Boiling Point: 184.8 °C at 760 mmHg
• PKA: 14.49±0.20(Predicted)
• Flash Point: 107.2 °C
• Density: 1.036 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Solubility.: Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 76.052429494
• Heavy Atom Count: 5
• Complexity: 20.9

Purity/Quality:

99% ^*data from raw suppliers

R-(-)-1,2-Propanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, Xn
• Hazard Codes: F,Xn
• Statements: 20-65-15-10
• Safety Statements: 24/25-43-7/8

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)O
• Isomeric SMILES: C[C@H](CO)O
• Uses: R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis.

Technology Process of R-1,2-Propanediol

There total 57 articles about R-1,2-Propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methyloxirane (75-56-9,16033-71-9) → (2R)-propane-1,2-diol (4254-14-2,63625-56-9) + (S)-Propylene oxide (16088-62-3)

Guidance literature:

With water; macrocyclic salen-type Co; In acetonitrile; at 23 ℃; for 24h;

DOI:10.1002/1521-3773(20020415)41:8<1374::AID-ANIE1374>3.0.CO;2-8

Reference yield: 46.0%

methyloxirane (75-56-9,16033-71-9) → (S)-1,2-Propanediol (4254-15-3,63625-56-9) + (2R)-propane-1,2-diol (4254-14-2,63625-56-9) + (S)-Propylene oxide (16088-62-3)

Guidance literature:

With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water; at 20 ℃; for 14h;

DOI:10.1021/ja016737l

Reference yield: 45.0%

methyloxirane (75-56-9,16033-71-9) → (S)-1,2-Propanediol (4254-15-3,63625-56-9) + (2R)-propane-1,2-diol (4254-14-2,63625-56-9) + (R)-propylene oxide (15448-47-2)

Guidance literature:

With water; chiral ((substituted salen)Co)2-InCl₃; at 20 ℃; for 2h;

DOI:10.1080/00397910600640354

upstream raw materials:

hydroxy-2-propanone

formaldehyd

methyloxirane

2-oxopropanal

Downstream raw materials:

(R)-propylene oxide

(R)-1-triphenylmethylmethoxy-2-propanol

(2R)-1-(benzyloxy)propan-2-ol

(R)-2-hydroxy-propyl methanesulfonate

Refernces

• 1、 Mashima, Kazushi,Nakamura, Tomoko,Matsuo, Yutaka,Tani, Kazuhide. "Convenient synthesis of anionic dinuclear ruthenium(II) complexes [NR2H2][{RuCl(diphosphine)}2(μ-Cl) 3] [diphosphine = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 2,2′-bis(di(p-tolyl)phosphino)-1,1′-binaphthyl, and 1,2-bis(diphenylphosphino)benzene]:". . p. 51 - 56. Retrieved 2000.
• 2、 -. "Method for synthesizing chiral 1,2-diol compound". Paragraph 0027; 0077-0080. . Retrieved 2021/07/21.
• 3、 Alluraiah, Gurrala,Sreenivasulu, Reddymasu,Chandrasekhar, Choragudi,Raju, Rudraraju Ramesh. "An alternative stereoselective total synthesis of (-)-pyrenophorol". . p. 2738 - 2743. Retrieved 2018/09/25.