9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Base Information

Chemical Name:9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine
CAS No.:867259-43-6
Molecular Formula:C₂₂H₃₂N₆O₃Si
Molecular Weight:456.62
Hs Code.:

Synonyms:9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Suppliers and Price of 9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

There total 5 articles about 9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 867259-42-5
9-[3,5-bis(tert-butyldimethylsilanyloxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

: 867259-43-6
9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jo050635m

Reference yield:

: 867259-40-3
2-amino-4-[3,5-bis(hydroxymethyl)anilino]-6-hydroxy-5-phenylazopyrimidine

: 867259-43-6
9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: Zn; AcOH / H₂O; ethanol; tetrahydrofuran / 1 h / Heating

3: 3.70 g / dimethylformamide / 15 h / 20 °C

4: 59 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo050635m

Reference yield:

: 2,5-diamino-6-[3,5-bis-(tert-butyl-dimethyl-silanyloxymethyl)-phenylamino]-3H-pyrimidin-4-one

: 867259-43-6
9-[3-(tert-butyldimethylsilanyloxymethyl)-5-(hydroxymethyl)phenyl]-2-N-[(dimethylamino)methylene]guanine

Guidance literature:: Multi-step reaction with 2 steps

1: 3.70 g / dimethylformamide / 15 h / 20 °C

2: 59 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo050635m