2-Methoxybiphenyl

Base Information

• Chemical Name: 2-Methoxybiphenyl
• CAS No.: 86-26-0
• Molecular Formula: C13H12 O
• Molecular Weight: 184.238
• Hs Code.: 2909309090
• European Community (EC) Number: 201-659-9
• NSC Number: 2148
• DSSTox Substance ID: DTXSID6052584
• Nikkaji Number: J33.860E
• Wikidata: Q81985143
• ChEMBL ID: CHEMBL3813993
• Mol file: 86-26-0.mol

Synonyms:2-phenylanisole;o-phenylanisole

Chemical Property of 2-Methoxybiphenyl

Chemical Property:

• Appearance/Colour: clear slightly yellow liquid after melting
• Vapor Pressure: 0.00928mmHg at 25°C
• Melting Point: 30-33 °C(lit.)
• Refractive Index: n20/D 1.61(lit.)
• Boiling Point: 274 °C(lit.)
• Flash Point: >230 °F
• PSA: 9.23000
• Density: 1.023 g/mL at 25 °C(lit.)
• LogP: 3.36220
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in toluene. Insoluble in water.
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 184.088815002
• Heavy Atom Count: 14
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxybiphenyl >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn:Harmful
• Statements: R33:Danger of cummulative effects.
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CC=CC=C2
• Uses: 2-Methoxybiphenyl is used as chemical and organic intermediates.

Technology Process of 2-Methoxybiphenyl

There total 313 articles about 2-Methoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + bis(2,2'-bisphenylylene)selenurane (19615-37-3) → dibenzo[b,d]selenophene (244-95-1) + 2-methoxy-1,1'-biphenyl (86-26-0,292625-97-9)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1246/cl.1994.889

Reference yield: 60.0%

perbenzoyl p-nitrophenyl carbonate (42464-09-5) + methoxybenzene (100-66-3) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 4-methoxylbiphenyl (613-37-6) + 2-methoxy-1,1'-biphenyl (86-26-0,292625-97-9) + 3-methoxybiphenyl (2113-56-6)

Guidance literature:

at 180 ℃; for 5h; Further byproducts given;

DOI:10.1021/ja00405a043

Reference yield: 30.0%

N-<(o-phenylthio)phenyl>formamide (1489-24-3) + methoxybenzene (100-66-3) → 2(3H)-Benzothiazolone (934-34-9) + 4-methoxylbiphenyl (613-37-6) + 2-methoxy-1,1'-biphenyl (86-26-0,292625-97-9) + 3-methoxybiphenyl (2113-56-6)

Guidance literature:

With di-tert-butyl peroxide; at 110 ℃; for 48h; Yield given;

DOI:10.1039/P19810003164

upstream raw materials:

diazomethane

2-Phenylphenol

6-methoxy-biphenyl-3,4'-dicarboxylic acid

3-amino-2'-methoxybiphenyl

Downstream raw materials:

1-(6-methoxy-biphenyl-3-yl)-ethanone

(5-benzyl-biphenyl-2-yl)-methyl ether

4-methoxy-3-phenyl-benzophenone

6-methoxy[1,1'-biphenyl]-3-carbaldehyde

Refernces

• 1、 Ding, Chengrong,Guan, Chenfei,Miao, Huihui,Zhang, Guofu,Zhao, Yiyong. "'Awaken' aryl sulfonyl fluoride: a new partner in the Suzuki-Miyaura coupling reaction". . p. 3560 - 3564. Retrieved 2022/03/07.
• 2、 Adhikari, Debashis,Dey, Dhananjay,Kundu, Abhishek,Pal, Subhankar,Roy, Monojit. "Aromatization as the driving force for single electron transfer towards C-C cross-coupling reactions". . p. 1934 - 1940. Retrieved 2022/04/07.