(2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

Base Information

• Chemical Name: (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran
• CAS No.: 454474-91-0
• Molecular Formula: C₃₀H₄₀O₇
• Molecular Weight: 512.643

Synonyms:(2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

Chemical Property of (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

There total 2 articles about (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pivaloyl chloride (3282-30-2) → (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran (454474-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / pyridine / 19 h / 0 - 20 °C

2: 201 mg / NaH; n-Bu₄NI / dimethylformamide; various solvent(s) / 2 h / 0 °C

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo020211h

Reference yield:

2,5-anhydro-D-mannitol (41107-82-8) → (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran (454474-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / pyridine / 19 h / 0 - 20 °C

2: 201 mg / NaH; n-Bu₄NI / dimethylformamide; various solvent(s) / 2 h / 0 °C

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo020211h

Reference yield:

(2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran (454474-91-0) → 2,5-anhydro-3,4-di-O-benzyl-D-mannitol (222555-96-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1021/jo020211h

upstream raw materials:

pivaloyl chloride

2,5-anhydro-D-mannitol

Downstream raw materials:

2,5-anhydro-3,4-di-O-benzyl-D-mannitol

(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

(2R,3S,4S,5R)-3,4-di-benzyloxy-2-trityloxy-5-(hydroxymethyl)tetrahydrofuran

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 454474-91-0 (2R,3S,4S,5R)-3,4-di-benzyloxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

Send

Send

Metric Ton KG G Pound L ML

Send

Send