(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Base Information

Chemical Name:(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride
CAS No.:1541198-81-5
Molecular Formula:C₁₄H₂₀ClNO₃*ClH
Molecular Weight:322.232
Hs Code.:

Synonyms:(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Chemical Property:

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Technology Process of (S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

There total 9 articles about (S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: (S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate trifluoroacetate

: 1541198-81-5
(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; for 0.5h;

Reference yield:

: 1541198-75-7
3-chloro-5-(2-hydroxypropan-2-yl)benzaldehyde

: 1541198-81-5
(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate / isopropyl alcohol / 4 h / Reflux; Inert atmosphere

2: hydrogenchloride / 2 h / Reflux

3: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / 20 °C / pH 8.2 / Enzymatic reaction

4: hydrogenchloride / 2 h / 20 °C

5: hydrogenchloride / 0.5 h

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; sodium hydroxide; In isopropyl alcohol;

Reference yield:

: 1541198-74-6
2-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)propan-2-ol

: 1541198-81-5
(S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / acetone / 1 h / 20 °C

2: ammonium acetate / isopropyl alcohol / 4 h / Reflux; Inert atmosphere

3: hydrogenchloride / 2 h / Reflux

4: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / 20 °C / pH 8.2 / Enzymatic reaction

5: hydrogenchloride / 2 h / 20 °C

6: hydrogenchloride / 0.5 h

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; toluene-4-sulfonic acid; sodium hydroxide; In isopropyl alcohol; acetone;