2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester

Base Information Edit

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester
CAS No.:851784-76-4
Molecular Formula:C₁₄H₁₇Cl₂NO₃
Molecular Weight:318.2
Hs Code.:
Mol file:851784-76-4.mol

Synonyms:tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Suppliers and Price of 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2-Boc-5,7-dichloro-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 95%
1g
$ 574.00

AK Scientific
2-Boc-5,7-dichloro-6-hydroxy-1,2,3,4-tetrahydroisoquinoline
1g
$ 937.00

Total 7 raw suppliers

Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester Edit

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Boc-5,7-dichloro-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester

There total 5 articles about 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1609545-55-2
C₉H₉Cl₂NO*C₇H₈O₃S

: 851784-76-4
tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With sodium carbonate; In methanol; at 20 ℃;

Reference yield: 52.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 158984-83-9
N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 851784-76-4
tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 5-chloro-6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: tert-butyl 5,8-dichloro-6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

Guidance literature:: N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline; With sulfuryl dichloride; acetic acid; at 20 ℃; for 3.5h;

di-tert-butyl dicarbonate; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 24424-99-5
di-tert-butyl dicarbonate

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 851784-76-4
tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: formaldehyd; 2-(3-methoxyphenyl)-1-ethanamine; With hydrogenchloride; In water; at 70 - 80 ℃;

With hydrogen bromide; In water; at 100 - 105 ℃;

di-tert-butyl dicarbonate; Further stages;