(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

Base Information

Chemical Name:(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide
CAS No.:1296137-07-9
Molecular Formula:C₂₄H₃₁N₃O₂
Molecular Weight:393.529
Hs Code.:

Synonyms:(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

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Technology Process of (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

There total 11 articles about (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1296136-97-4
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1H-pyrrol-2-yl)acrylamide

: 74-88-4
methyl iodide

: 1296137-07-9
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 9h;
DOI:10.1016/j.ejmech.2011.01.034

Reference yield:

: 408538-69-2
4-piperidin-4-ylbutyric acid methyl ester

: 1296137-07-9
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

3: triethylamine / dichloromethane / 2 h / 20 °C

4: N,N-dimethyl-formamide / 8 h / 50 °C

5: hydrazine hydrate / ethanol / 24 h / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

7: sodium hydride / N,N-dimethyl-formamide / 9 h / 55 °C

With pyridine; lithium aluminium tetrahydride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.034

Reference yield:

: 1041756-57-3
[4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

: 1296137-07-9
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-methyl-1H-pyrrol-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 9 h / 55 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.034