5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Base Information

Chemical Name:5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one
CAS No.:1429439-25-7
Molecular Formula:C₂₈H₂₈ClNO₆
Molecular Weight:509.986
Hs Code.:
Mol file:1429439-25-7.mol

Synonyms:5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Suppliers and Price of 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

There total 6 articles about 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

: 1429439-24-6
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1429439-25-7
5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Guidance literature:: 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -40 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 14698-29-4
oxolinic Acid

: 1429439-25-7
5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; potassium nitrate / 1 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 1 h / 2585.81 Torr

3.1: hydrogenchloride; sodium nitrite / water / 5 h / 20 - 45 °C / Inert atmosphere

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

5.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

6.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

6.2: 3.5 h / -40 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; palladium on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; potassium nitrate; triethylamine; potassium iodide; potassium hydroxide; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1429439-23-5
4-methoxybenzyl 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylate

: 1429439-25-7
5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

2.2: 3.5 h / -40 °C / Inert atmosphere

With water; triethylamine; potassium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol;