8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

Base Information

Chemical Name:8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine
CAS No.:1253848-91-7
Molecular Formula:C₂₀H₂₄N₆O₄S
Molecular Weight:444.514
Hs Code.:

Synonyms:8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

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Chemical Property of 8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

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Technology Process of 8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

There total 7 articles about 8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1253847-01-6
8-ethyl-2-(4-methoxybenzylsulfanyl)-9-methyl-6-morpholino-9H-purine

: 61010-34-2
3-nitro-4-methoxybenzyl bromide

: 1253848-91-7
8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

Guidance literature:: 8-ethyl-2-(4-methoxybenzylsulfanyl)-9-methyl-6-morpholino-9H-purine; With trifluoroacetic acid; In methoxybenzene; at 80 ℃;

With triethylamine; In methoxybenzene; Cooling with ice;

3-nitro-4-methoxybenzyl bromide;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1253848-91-7
8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1.75 h / 100 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / 100 °C

3.1: methanol / 20 °C

4.1: 80 °C

5.1: sodium nitrite; acetic acid / water / 5 h / 20 °C

5.3: 4 h / 760.05 Torr

6.1: methanol / 3 h / 20 °C

7.1: trifluoroacetic acid / methoxybenzene / 80 °C

7.2: Cooling with ice

With acetic acid; N,N-dimethyl-aniline; triethylamine; trifluoroacetic acid; sodium nitrite; trichlorophosphate; In methanol; water; methoxybenzene; N,N-dimethyl-formamide;

Reference yield:

: 869119-61-9
2-(4-methoxybenzylsulfanyl)-4-methylamino-6-morpholino pyrimidine

: 1253848-91-7
8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; acetic acid / water / 5 h / 20 °C

1.3: 4 h / 760.05 Torr

2.1: methanol / 3 h / 20 °C

3.1: trifluoroacetic acid / methoxybenzene / 80 °C

3.2: Cooling with ice

With acetic acid; trifluoroacetic acid; sodium nitrite; In methanol; water; methoxybenzene;