α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

Base Information

Chemical Name:α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid
CAS No.:292045-47-7
Molecular Formula:C₃₀H₄₃N₇O₈Si₂
Molecular Weight:685.885
Hs Code.:

Synonyms:α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

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Chemical Property of α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

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Technology Process of α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

There total 7 articles about α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 292045-49-9
α-[2-(trimethylsilyl)ethoxy]-L-glutamic acid

: 292045-48-8
(6-([4-(imidazol-1-ylcarbonyl)phenylamino]methyl)-4-oxo-3,4-dihydro-pteridin-2-yl)-carbamic acid 2-trimethylsilylethyl ester

: 292045-47-7
α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

Guidance literature:: With 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; In dimethyl sulfoxide; at 20 ℃; for 21h;
DOI:10.1021/jo000132a

Reference yield:

: 59-30-3
folic acid

: 292045-47-7
α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 12.1 g / carboxypeptidase G; ZnCl₂; Tris-HCl buffer / 336000 h / 30 °C / pH 3.7

2.1: triethylamine / dimethylsulfoxide / 3.5 h / 20 °C

2.2: 50 percent / dimethylsulfoxide / 5 h / 20 °C

3.1: 71 percent / MTBD / dimethylsulfoxide / 21 h / 20 °C

With Tris-HCl buffer; carboxypeptidase G; triethylamine; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; zinc(II) chloride; In dimethyl sulfoxide; 1.1: Hydrolysis / 2.1: Substitution / 2.2: Substitution / 3.1: Substitution;
DOI:10.1021/jo000132a

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 292045-47-7
α-[2-(trimethylsilyl)ethoxy]-2-N-[2-(trimethylsilyl)ethoxycarbonyl]folic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / CDI / CH₂Cl₂ / 18 h / 20 °C

2: 57 percent / TsOH-H₂O / H₂O; dioxane / 3 h / 60 °C

3: 71 percent / MTBD / dimethylsulfoxide / 21 h / 20 °C

With toluene-4-sulfonic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 1: Esterification / 2: Hydrolysis / 3: Substitution;
DOI:10.1021/jo000132a