tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate
CAS No.:912369-52-9
Molecular Formula:C₂₉H₃₆N₆O₄S₂
Molecular Weight:596.775
Hs Code.:

Synonyms:tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

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Chemical Property of tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

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Technology Process of tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

There total 9 articles about tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912369-51-8
tert-butyl (3S)-3-{[7-cyano-2-(4-piperazin-1-ylphenyl)thieno[3,2-c]pyridin-4-yl]amino}piperidine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 912369-52-9
tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 912368-70-8
tert-butyl (3S)-3-[(7-cyano-2-bromothieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

: 912369-52-9
tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 80 °C

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

With caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 912368-67-3
(2Z)-3-cyano-3-(2-thienyl)acrylic acid potassium salt

: 912369-52-9
tert-butyl (3S)-3-[(7-cyano-2-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}thieno[3,2-c]pyridin-4-yl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: sodium azide / 1,4-dioxane; water / 1.5 - 2.5 h / 0 - 20 °C

3: tributyl-amine / diphenylether; dichloromethane / 2.17 h / 210 °C

4: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

5: trichlorophosphate / Heating / reflux

6: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

7: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 80 °C

8: triethylamine / tetrahydrofuran / 1 h / 20 °C

With N-Bromosuccinimide; sodium azide; oxalyl dichloride; tributyl-amine; potassium carbonate; caesium carbonate; acetic acid; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; dichloromethane; water; N,N-dimethyl-formamide;