1-[2-(acetylamino)phenyl]-2-bromoethanone

Base Information

• Chemical Name: 1-[2-(acetylamino)phenyl]-2-bromoethanone
• CAS No.: 4688-64-6
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.099
• Mol file: 4688-64-6.mol

Synonyms:1-[2-(acetylamino)phenyl]-2-bromoethanone

Chemical Property of 1-[2-(acetylamino)phenyl]-2-bromoethanone

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

N-[2-(2-BROMOACETYL)PHENYL]ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(acetylamino)phenyl]-2-bromoethanone

There total 2 articles about 1-[2-(acetylamino)phenyl]-2-bromoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-(2-acetylphenyl)acetamide (5234-26-4) → 1-[2-(acetylamino)phenyl]-2-bromoethanone (4688-64-6)

Guidance literature:

With copper(ll) bromide; In chloroform; ethyl acetate; for 8h; Heating;

DOI:10.3987/com-97-7949

Reference yield:

1-(2-amino-phenyl)-2-bromo-ethanone (58585-01-6) + acetic anhydride (108-24-7) → 1-[2-(acetylamino)phenyl]-2-bromoethanone (4688-64-6)

Guidance literature:

DOI:10.1002/hlca.193702001130

Reference yield: 68.7%

4-amino-1-benzylpiperidine (50541-93-0) + 1-[2-(acetylamino)phenyl]-2-bromoethanone (4688-64-6) + sodium isocyanate (917-61-3) → 4-[2-(acetylamino)phenyl]-1,3-dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-imidazol-2-one

Guidance literature:

4-amino-1-benzylpiperidine; 1-[2-(acetylamino)phenyl]-2-bromoethanone; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

sodium isocyanate; In dichloromethane; acetic acid; Cooling with ice;

upstream raw materials:

1-(2-amino-phenyl)-2-bromo-ethanone

acetic anhydride

N-(2-acetylphenyl)acetamide

Downstream raw materials:

1H,1H'-2,2'-Biindolylidene-3,3'-dione

1-(2-amino-phenyl)-2-bromo-ethanone

3-(2-aminophenyl)-3-oxopropanenitrile

1-(2-acetylamino-phenyl)-2-(N-benzoyl-anilino)-ethanone

Refernces

• 1、 -. "SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, THE USE OF THE SAME AS MEDICAMENTS, AND MEDICAMENT CONTAINING SUCH COMPOUNDS". Page/Page column 50. . Retrieved 2008/06/13.
• 2、 Alkhathlan, Hamad Z.,Al-Farhan, Khalid A.. "Synthesis of 2,3-disubstituted 4-oxoquinolines and 3-substituted fused 4-oxoquinolines". . p. 641 - 655. Retrieved 2007/10/03.