2-Amino-2'-bromoacetophenone

Base Information

• Chemical Name: 2-Amino-2'-bromoacetophenone
• CAS No.: 58585-01-6
• Molecular Formula: C8H8BrNO
• Molecular Weight: 214.062
• DSSTox Substance ID: DTXSID50479025
• Wikidata: Q82312871
• Mol file: 58585-01-6.mol

Synonyms:2-AMINO-2'-BROMOACETOPHENONE;58585-01-6;2-amino-1-(2-bromophenyl)ethanone;2-AMINO-1-(2-BROMOPHENYL)ETHAN-1-ONE;876108-77-9;2-Amino-2 inverted exclamation mark -bromoacetophenone;SCHEMBL8744733;DTXSID50479025;AKOS005264097;EN300-147089

Chemical Property of 2-Amino-2'-bromoacetophenone

Chemical Property:

• Appearance/Colour: hellgelb solid
• Melting Point: 107 °C(ethanol), 83 - 85 °C(diethyl ether/petroleum ether)
• PSA: 43.09000
• LogP: 2.42760
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.97893
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98% ^*data from raw suppliers

2-AMINO-2'-BROMOACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)CN)Br

Technology Process of 2-Amino-2'-bromoacetophenone

There total 4 articles about 2-Amino-2'-bromoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-[2-(acetylamino)phenyl]-2-bromoethanone (4688-64-6) → 1-(2-amino-phenyl)-2-bromo-ethanone (58585-01-6)

Guidance literature:

With hydrogenchloride; In ethanol; at 80 ℃; for 2h;

DOI:10.3987/com-97-7949

Reference yield:

N-(2-acetylphenyl)acetamide (5234-26-4) → 1-(2-amino-phenyl)-2-bromo-ethanone (58585-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / CuBr₂ / ethyl acetate; CHCl₃ / 8 h / Heating

2: 55 percent / concd HCl / ethanol / 2 h / 80 °C

With hydrogenchloride; copper(ll) bromide; In ethanol; chloroform; ethyl acetate;

DOI:10.3987/com-97-7949

Reference yield:

→ 1-(2-amino-phenyl)-2-bromo-ethanone (58585-01-6)

Guidance literature:

With sulfuric acid; copper;

DOI:10.1002/hlca.193702001130

upstream raw materials:

1-[2-(acetylamino)phenyl]-2-bromoethanone

sulfuric acid

2-bromo-1-(2-nitrophenyl)ethanone

N-(2-acetylphenyl)acetamide

Downstream raw materials:

2-(2-amino-phenacyl)-1-methyl-3,4-dihydro-isoquinolinium; bromide

3-(2-aminophenyl)-3-oxopropanenitrile

1H,1H'-2,2'-Biindolylidene-3,3'-dione

2-(2-amino-phenyl)-3-anilino-quinoline-4-carboxylic acid

Refernces