4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester
• CAS No.: 260806-72-2
• Molecular Formula: C₂₇H₂₉NO₃
• Molecular Weight: 415.532

Synonyms:4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester

Chemical Property of 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester

There total 2 articles about 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester (260806-71-1) + 1,3-bis-(diphenylphosphino)propane (6737-42-4) → 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester (260806-72-2)

Guidance literature:

With CO; triethylamine; palladium diacetate; In methanol; dimethyl sulfoxide;

Reference yield: 84.0%

methanol (67-56-1) + trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester (260806-71-1) + carbon monoxide (201230-82-2) → 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester (260806-72-2)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In dimethyl sulfoxide; at 70 ℃;

DOI:10.1016/j.bmcl.2009.11.113

Reference yield: 91.0%

4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester (260806-72-2) + ethylmagnesium bromide (925-90-6) → C30H37NO2 (1207551-97-0)

Guidance literature:

In tetrahydrofuran; at 0 - 50 ℃;

DOI:10.1016/j.bmcl.2009.11.113

upstream raw materials:

trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester

1,3-bis-(diphenylphosphino)propane

methanol

carbon monoxide

Downstream raw materials:

4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid hydrazide

C₃₀H₃₇NO₂

C₂₈H₃₂N₂O₂

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