{(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester

Base Information

• Chemical Name: {(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester
• CAS No.: 114032-16-5
• Molecular Formula: C₂₁H₃₀O₅S
• Molecular Weight: 394.532
• Mol file: 114032-16-5.mol

Synonyms:{(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester

Chemical Property of {(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester

There total 8 articles about {(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[(1S,2R,5R)-2-(3-Hydroxy-1-methylene-propyl)-5-methyl-cyclohexyl]-acetic acid methyl ester (114032-15-4) + p-toluenesulfonyl chloride (98-59-9) → {(1S,2R,5R)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester (114032-16-5)

Guidance literature:

In pyridine; 1) 1 h, 0 deg C, 2) 12 h, 5 deg C;

Reference yield:

(S)-Citronellal (5949-05-3) → {(1R,2S,5S)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester (114032-16-5)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridinium acetate / CH₂Cl₂

2: FeCl₃/Al₂O₃

3: NaCl,Me₂SO / H₂O

4: (CH₂O)n / CH₂Cl₂

5: pyridine

With aluminum oxide; formaldehyd; pyridinium acetate; iron(III) chloride; dimethyl sulfoxide; sodium chloride; In pyridine; dichloromethane; water;

Reference yield:

2-((1S,2S,5S)-2-Isopropenyl-5-methyl-cyclohexyl)-malonic acid dimethyl ester (130451-45-5) → {(1R,2S,5S)-5-Methyl-2-[1-methylene-3-(toluene-4-sulfonyloxy)-propyl]-cyclohexyl}-acetic acid methyl ester (114032-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaCl,Me₂SO / H₂O

2: (CH₂O)n / CH₂Cl₂

3: pyridine

With formaldehyd; dimethyl sulfoxide; sodium chloride; In pyridine; dichloromethane; water;

upstream raw materials:

[(1S,2R,5R)-2-(3-Hydroxy-1-methylene-propyl)-5-methyl-cyclohexyl]-acetic acid methyl ester

p-toluenesulfonyl chloride

dimethyl (1'R,2'R,5'R)-2-(2'-isopropenyl-5'-methylcyclohex-1'-yl)-propane-1,3-dioate

((1S,2R,5R)-2-Isopropenyl-5-methyl-cyclohexyl)-acetic acid methyl ester

Downstream raw materials:

[(1S,2R,5R)-2-(3-Iodo-1-methylene-propyl)-5-methyl-cyclohexyl]-acetic acid methyl ester