(R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Base Information

• Chemical Name: (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal
• CAS No.: 1352335-26-2
• Molecular Formula: C₁₅H₁₇NO₄
• Molecular Weight: 275.304
• Mol file: 1352335-26-2.mol

Synonyms:(R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property of (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

There total 2 articles about (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-methoxyphenyl)maleimide (17392-68-6) + isobutyraldehyde (78-84-2) → (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1352335-26-2)

Guidance literature:

With C₂₉H₄₉N₃O₂S; benzoic acid; In chloroform; at 20 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2011.10.002

Reference yield:

1-(2-methoxyphenyl)maleimide (17392-68-6) + isobutyraldehyde (78-84-2) → (S)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1352335-22-8) + (R)-2-(1-(2-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1352335-26-2)

Guidance literature:

With 1H-imidazole; 1-[(1S,2S)-2-aminocyclohexyl]-2,3-diisopropylguanidine; In water; N,N-dimethyl-formamide; at 0 ℃; for 48h; Overall yield = 95%; enantioselective reaction;

DOI:10.1002/ejoc.201300492

upstream raw materials:

1-(2-methoxyphenyl)maleimide

isobutyraldehyde