Technology Process of Benzoic acid (1R,2S,3R,5S,6R)-3-benzyloxy-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-6-(methoxy-methyl-carbamoyl)-heptyl ester
There total 9 articles about Benzoic acid (1R,2S,3R,5S,6R)-3-benzyloxy-1-isopropyl-2-methoxy-5-(4-methoxy-benzyloxy)-6-(methoxy-methyl-carbamoyl)-heptyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / NaH / tetrahydrofuran; dimethylformamide / 12 h / Ambient temperature
2: 81 percent / BF3*Et2O / CH2Cl2 / 24 h / Ambient temperature
3: DMAP, pyridine / CH2Cl2 / 72 h / Ambient temperature
4: NBS, H2O / acetone / 0.17 h / -23 °C
5: 1.) n-Bu2BOTf, Et3N / 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, -78 deg C, 1.5 h
6: 86 percent / trifluoromethanesulfonic acid / diethyl ether / 0.08 h / Ambient temperature
7: LiOH*H2O, aq. H2O2 / tetrahydrofuran / 11 h / Ambient temperature
8: diethylphosphoryl cyanide, Et3N / dimethylformamide / 2 h / Ambient temperature
With
pyridine; dmap; lithium hydroxide; N-Bromosuccinimide; diethylphosphoryl cyanide; trifluorormethanesulfonic acid; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; dihydrogen peroxide; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4020(96)00811-3
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 81 percent / BF3*Et2O / CH2Cl2 / 24 h / Ambient temperature
2: DMAP, pyridine / CH2Cl2 / 72 h / Ambient temperature
3: NBS, H2O / acetone / 0.17 h / -23 °C
4: 1.) n-Bu2BOTf, Et3N / 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, -78 deg C, 1.5 h
5: 86 percent / trifluoromethanesulfonic acid / diethyl ether / 0.08 h / Ambient temperature
6: LiOH*H2O, aq. H2O2 / tetrahydrofuran / 11 h / Ambient temperature
7: diethylphosphoryl cyanide, Et3N / dimethylformamide / 2 h / Ambient temperature
With
pyridine; dmap; lithium hydroxide; N-Bromosuccinimide; diethylphosphoryl cyanide; trifluorormethanesulfonic acid; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4020(96)00811-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-Bu2BOTf, Et3N / 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, -78 deg C, 1.5 h
2: 86 percent / trifluoromethanesulfonic acid / diethyl ether / 0.08 h / Ambient temperature
3: LiOH*H2O, aq. H2O2 / tetrahydrofuran / 11 h / Ambient temperature
4: diethylphosphoryl cyanide, Et3N / dimethylformamide / 2 h / Ambient temperature
With
lithium hydroxide; diethylphosphoryl cyanide; trifluorormethanesulfonic acid; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3
