8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

Base Information

Chemical Name:8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde
CAS No.:99050-45-0
Molecular Formula:C₂₃H₂₄O₅
Molecular Weight:380.441
Hs Code.:

Synonyms:8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

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Chemical Property of 8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

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Technology Process of 8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

There total 9 articles about 8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 78-94-4,25038-87-3
methyl vinyl ketone

: 99050-44-9
3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

: 99050-45-0
8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

Guidance literature:: With triethylamine; In benzene; for 168h;
DOI:10.1139/v85-367

Reference yield:

: 717-94-2
3-(3,5-dimethoxyphenyl)propionic acid

: 99050-45-0
8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: oxalyl chloride / DMF / benzene / 0.5 h / Ambient temperature

2: diethyl ether

3: Ag₂O / 3 h / 60 °C

4: 96 percent / KOH / methanol; H₂O / 3 h

5: 87 percent / polyphosphoric acid / 4 h / 100 - 110 °C

6: 77 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg. C; 2.) room temperature, 0.5 h

7: 95 percent / K₂CO₃ / acetone / 24 h / Heating

8: 100 percent / NaOMe

9: 100 percent / triethylamine / benzene / 168 h

With potassium hydroxide; PPA; oxalyl dichloride; sodium methylate; boron trichloride; potassium carbonate; triethylamine; silver(l) oxide; N,N-dimethyl-formamide; In methanol; diethyl ether; dichloromethane; water; acetone; benzene;
DOI:10.1139/v85-367

Reference yield:

: 883-07-8
6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

: 99050-45-0
8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg. C; 2.) room temperature, 0.5 h

2: 95 percent / K₂CO₃ / acetone / 24 h / Heating

3: 100 percent / NaOMe

4: 100 percent / triethylamine / benzene / 168 h

With sodium methylate; boron trichloride; potassium carbonate; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1139/v85-367