3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

Base Information

Chemical Name:3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone
CAS No.:99050-44-9
Molecular Formula:C₁₉H₁₈O₄
Molecular Weight:310.35
Hs Code.:

Synonyms:3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

Chemical Property:

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Technology Process of 3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

There total 8 articles about 3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 99050-43-8
8-Benzyloxy-6-methoxytetralone

: 109-94-4
formic acid ethyl ester

: 99050-44-9
3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

Guidance literature:: With sodium methylate;
DOI:10.1139/v85-367

Reference yield:

: 717-94-2
3-(3,5-dimethoxyphenyl)propionic acid

: 99050-44-9
3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl chloride / DMF / benzene / 0.5 h / Ambient temperature

2: diethyl ether

3: Ag₂O / 3 h / 60 °C

4: 96 percent / KOH / methanol; H₂O / 3 h

5: 87 percent / polyphosphoric acid / 4 h / 100 - 110 °C

6: 77 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg. C; 2.) room temperature, 0.5 h

7: 95 percent / K₂CO₃ / acetone / 24 h / Heating

8: 100 percent / NaOMe

With potassium hydroxide; PPA; oxalyl dichloride; sodium methylate; boron trichloride; potassium carbonate; silver(l) oxide; N,N-dimethyl-formamide; In methanol; diethyl ether; dichloromethane; water; acetone; benzene;
DOI:10.1139/v85-367

Reference yield:

: 883-07-8
6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

: 99050-44-9
3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg. C; 2.) room temperature, 0.5 h

2: 95 percent / K₂CO₃ / acetone / 24 h / Heating

3: 100 percent / NaOMe

With sodium methylate; boron trichloride; potassium carbonate; In dichloromethane; acetone;
DOI:10.1139/v85-367