1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

Base Information

Chemical Name:1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide
CAS No.:1561949-61-8
Molecular Formula:C₁₈H₁₂ClF₃IN₃O₂
Molecular Weight:521.665
Hs Code.:

Synonyms:1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

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Technology Process of 1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

There total 4 articles about 1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-1H-indazole-6-carboxylic acid

: 124-40-3
dimethyl amine

: 1561949-61-8
1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

Guidance literature:: With triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 170487-40-8
1H-indazole-6-carboxylic acid methyl ester

: 1561949-61-8
1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; potassium hydroxide / N,N-dimethyl acetamide / 1 h / 20 °C / Cooling with ice

2: dmap; triethylamine / dichloromethane / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 20 °C

4: triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) / dichloromethane / 2 h / 20 °C

With dmap; water; iodine; triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); potassium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1561949-61-8
1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-iodo-N,N-dimethyl-1H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; sodium nitrite / water / 20 °C / Cooling with ice

2: iodine; potassium hydroxide / N,N-dimethyl acetamide / 1 h / 20 °C / Cooling with ice

3: dmap; triethylamine / dichloromethane / 20 °C

4: lithium hydroxide; water / tetrahydrofuran / 20 °C

5: triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) / dichloromethane / 2 h / 20 °C

With dmap; water; iodine; acetic acid; triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); potassium hydroxide; lithium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;